Sensitive Immunodetection of Severe Acute Respiratory Syndrome Coronavirus 2 Variants of Concern 501Y.V2 and 501Y.V1중증 급성 호흡기 증후군 코로나바이러스 2 우려의 변종 501Y.V2 및 501Y.V1의 민감성 면역 검출Article Published on 2021-08-162022-09-11 Journal: The Journal of Infectious Diseases [Category] MERS, SARS, 변종, 진단, 치료기술, 치료제, [키워드] 501Y.V1 501Y.V2 accumulation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 African antibodies antigen detection Combination concern coronavirus coronavirus 2 diagnostics Effectiveness Epitopes house Laboratory monoclonal antibodies Mutation Nasopharyngeal swab Nasopharyngeal swab specimens polymerase chain Quantitative respiratory SARS-CoV-2 SARS-CoV-2 variant sensitive severe acute respiratory syndrome Coronavirus South specificity Spike protein spike protein. variant variants variants of concern wild type [DOI] 10.1093/infdis/jiab278 PMC 바로가기 [Article Type] Article
Longitudinal and proteome-wide analyses of antibodies in COVID-19 patients reveal features of the humoral immune response to SARS-CoV-2COVID-19 환자의 항체에 대한 종단 및 프로테옴 전체 분석은 SARS-CoV-2에 대한 체액성 면역 반응의 특징을 보여줍니다Article Published on 2021-07-272022-09-11 Journal: Journal of advanced research [Category] MERS, SARS, 변종, 진단, [키워드] 501Y.V1 501Y.V2 amino acids Analysis analysis antibodies antibody assays B-cell B.1.1.7 B.1.351 B.1.617 Brazil country COVID-19 COVID-19 patient COVID-19 patients develop dominant epitope effective Epidemic epitope Epitopes feature FIVE global health Health humoral immune response IgA IgG IgM immune Immune escape immune response immune responses immune system immunogenic peptide India Infection information Intensive key amino acid lead linear longitudinal measure mild patients morbidity morbidity and mortality Neutralization assay Neutralizing antibodies new SARS-CoV-2 non-structural proteins peptides performed proteomics resource respond Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pandemic SARS-CoV-2. severe and mild patients South Africa Spread Treatment Vaccine Vaccine design variant variants Viral viral infection [DOI] 10.1016/j.jare.2021.07.008 PMC 바로가기 [Article Type] Article
The 501Y.V2 SARS-CoV-2 variant has an intermediate viral load between the 501Y.V1 and the historical variants in nasopharyngeal samples from newly diagnosed COVID-19 patients501Y.V2 SARS-CoV-2 변종은 501Y.V1과 새로 진단된 COVID-19 환자의 비인두 샘플의 과거 변이 사이의 중간 바이러스 부하를 가지고 있습니다.Article Published on 2021-07-012022-09-11 Journal: The Journal of Infection [Category] MERS, SARS, 변종, 진단, [키워드] 501Y.V1 501Y.V2 Abstract COVID-19 patient diagnosed nasopharyngeal sample SARS-CoV-2 SARS-CoV-2 variant variant variants Viral Viral load Viral load. [DOI] 10.1016/j.jinf.2021.04.023 PMC 바로가기 [Article Type] Article
Live Virus Neutralisation of the 501Y.V1 and 501Y.V2 SARS-CoV-2 Variants following INO-4800 Vaccination of Ferrets흰 족제비의 INO-4800 백신 접종 후 501Y.V1 및 501Y.V2 SARS-CoV-2 변이체의 살아있는 바이러스 중화Immunology Published on 2021-06-252022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 진단, [키워드] 501Y.V1 501Y.V2 affecting biomolecular modelling comparable Course COVID-19 COVID-19 pandemic COVID-19 vaccine COVID-19 vaccines DNA vaccine dose effective ferret ferrets immune responses in silico Influenza influenza pandemic INO-4800 investigated less media morbidity and mortality neutralisation neutralisation titre Neutralisation titres Neutralising Antibodies neutralising antibody nucleic acid nucleic acid vaccine Nucleic acid-based vaccines over pandemic PROTECT reported SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 variant SARS-CoV-2 variants sera supported titre titres vaccine-induced immune response Vaccine-induced immunity variant variants virus isolate [DOI] 10.3389/fimmu.2021.694857 PMC 바로가기 [Article Type] Immunology
Dying of VOC-202012/01 — multimodal investigations in a death case of the SARS-CoV-2 variantVOC-202012/01의 죽음 — SARS-CoV-2 변종 사망 사례의 다중 모드 조사Case Reports Published on 2021-06-052022-09-10 Journal: International Journal of Legal Medicine [Category] MERS, SARS, 변종, [키워드] 501Y.V1 acute respiratory distress syndrome B.1.1.7 B.1.1.7 lineage Complication comprehensive analysis conducted Coronavirus-disease-19 country death case death cases described Dying initiated lung damage macroscopic pandemic Patient Postmortem predominant pulmonary damage Pulmonary embolism pulmonary embolisms radiologic reported respiratory respiratory distress Respiratory distress syndrome respiratory infections SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome-coronavirus-2 the disease the SARS-CoV-2 today Vaccination strategies Vaccination strategy variant Variant of Concern-202012/01 variants VOC-202012/01 [DOI] 10.1007/s00414-021-02618-8 PMC 바로가기 [Article Type] Case Reports
A Biochemical Perspective of the Nonstructural Proteins (NSPs) and the Spike Protein of SARS CoV-2비구조 단백질(NSP)과 SARS CoV-2의 스파이크 단백질에 대한 생화학적 관점Review Published on 2021-06-012022-09-11 Journal: The protein journal [Category] SARS, 변종, [키워드] 501Y.V1 501Y.V2 ACE2 receptor aspartate caused change Chemistry D614G effort ENhance Enzymes global pandemic glycine Host increasingly Interaction N501Y nonstructural protein nonstructural proteins Nsp12 nsp13 nsp14 Nsp15 Nsp3 nsp5 pandemic position Proteases Proteins Receptor binding domain SARS CoV SARS CoV-2 Spike protein strain the Spike the spike protein variant Viral proteins Viral proteins. virus [DOI] 10.1007/s10930-021-09967-8 PMC 바로가기 [Article Type] Review
Increased elastase sensitivity and decreased intramolecular interactions in the more transmissible 501Y.V1 and 501Y.V2 SARS-CoV-2 variants’ spike protein–an in silico analysisResearch Article Published on 2021-05-262022-10-28 Journal: PLoS ONE [Category] COVID-19, SARS, [키워드] 501Y.V1 501Y.V2 Analysis appear computational tools contribute death faster in silico Increased increased risk information intramolecular interaction Neutrophil elastase new SARS-CoV-2 Potential treatment Receptor binding domain reduced SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sensitivity Spike protein Spread stability Transmissibility variant virus Wuhan [DOI] 10.1371/journal.pone.0251426 PMC 바로가기 [Article Type] Research Article
Emergence and rapid transmission of SARS-CoV-2 B.1.1.7 in the United States미국에서 SARS-CoV-2 B.1.1.7의 출현 및 빠른 전파Article Published on 2021-05-132022-09-11 Journal: Cell [Category] Fulltext, SARS, 변종, 치료기술, 치료제, [키워드] 501Y.V1 B.1.1.7 B.1.1.7 variant community transmission country COVID-19 dominant doubling emergence fraction genomic Genomic epidemiology genomic sequencing independent investigated Logistic morbidity and mortality Prevalence S gene S gene target failure SARS-CoV-2 the United State trajectory Transmission transmission of SARS-CoV-2 United Kingdom United States variant Variant of concern. VOC-202012/01 [DOI] 10.1016/j.cell.2021.03.052 PMC 바로가기 [Article Type] Article
Mutation in a SARS-CoV-2 Haplotype from Sub-Antarctic Chile Reveals New Insights into the Spike’s DynamicsArticle Published on 2021-05-112022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] 501Y.V1 501Y.V2 accompanied B.1.1.28.1 B.1.1.7 B.1.351 Comparative continuous surveillance COVID19 D614G domain Dynamics Haplotype higher infectivity highest incidence rate indicated insight Lineage lineages molecular molecular analysis molecular mechanism mutant Mutation New nine Occurrence P.1 Receptor binding domain Region replaced resulting SARS-CoV-2 SARS-CoV-2 strains SARS-CoV-2 variants SARS-CoV2 significant increase Spike protein strain synergistic variant Variation virulence [DOI] 10.3390/v13050883 PMC 바로가기 [Article Type] Article
Multiplex qPCR discriminates variants of concern to enhance global surveillance of SARS-CoV-2Multiplex qPCR은 SARS-CoV-2의 글로벌 감시를 강화하기 위해 우려 변종을 식별합니다.Methods and Resources Published on 2021-05-072022-08-13 Journal: PLoS Biology [Category] Medicine and Health Sciences, SARS, 변종, 치료기술, 치료제, [키워드] 501Y.V1 501Y.V2 acute respiratory syndrome coronavirus B.1.1.7 B.1.351 Brazil can not circulating coronavirus coronavirus 2 COVID-19 Deletion detect ENhance escape gene target immune responses Laboratory lack lineages Local multiplex ORF1a other variant other variants P.1 PCR assay qPCR respiratory SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Sequencing severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 South Africa Spread Surveillance TaqPath Thermo Fisher these viruses Transmissibility United Kingdom variant variants variants of concern viruses VoC [DOI] 10.1371/journal.pbio.3001236 PMC 바로가기 [Article Type] Methods and Resources